Zebinix: new for epilepsy

29 October 2009

Zebinix (eslicarbazepine acetate) has been launched as an adjunctive treatment for partial-onset seizures with or without secondary generalisation.

Eslicarbazepine acetate is a carboxamide derivative.

The drug's exact mechanism of action is unknown, but it is suggested that it works by stabilising the inactivated state of voltage-gated sodium channels, preventing their return to the activated state therefore sustaining repetitive neuronal firing.

Zebinix must be added to existing anticonvulsant therapy and the dose increased gradually. Zebinix is licensed for the management of epilepsy in adults; caution should be exercised when managing elderly patients and it is not recommended for use in children.

View Zebinix drug record

Further information: Eisai

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