Yondelis

Yondelis (trabectedin) is an new treatment for advanced soft tissue sarcoma.

Treatment is indicated in patients intolerant to, or who have failed to respond to, anthracyclines and ifosfamide.

PHARMACOLOGY

Trabectedin binds to the minor groove of DNA, bending the helix to the major groove. This binding to DNA triggers a cascade of events affecting several transcription factors, DNA binding proteins, and DNA repair pathways, resulting in perturbation of the cell cycle.


Trabectedin has been shown to exert antiproliferative in vitro and in vivo activity against a range of human tumour cell lines and experimental tumours.

View Yondelis drug record

Further information: Pharma Mar

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