Leo Pharma has launched Xamiol gel, a combination of calcipotriol + betamethasone, for the treatment of scalp psoriasis.


Calcipotriol is a vitamin D analogue that is thought to normalise the rate of skin cell turnover. Betamethasone is a potent corticosteroid with recognised anti-inflammatory effects.

Xamiol allows both of these active ingredients to be combined in a gel suitable for once-daily administration to the scalp.

In a clinical trial1 involving over 1,500 patients with scalp psoriasis the efficacy of Xamiol gel was compared to calcipotriol in the gel vehicle, betamethasone dipropionate in the gel vehicle or the gel vehicle alone, all used once daily.

The two-compound formulation (Xamiol) was significantly more effective than either compound or the vehicle alone from week two of treatment onwards. At week two, 57.5 per cent of patients achieved control (defined as absent or very mild disease) in the Xamiol group, compared to 18.8 per cent, 47.1 per cent and 11.8 per cent in the calcipotriol, betamethasone and placebo groups, respectively. At week four, 66.9 per cent of patients achieved control in the Xamiol group, compared to 23.5 per cent, 54.7 per cent and 14.7 per cent in the calcipotriol, betamethasone and placebo groups, respectively.

View Xamiol drug record

1. Jemec G, Ganslandt C, Ortonne J et al. A new scalp formulation of calcipotriene plus betamethasone compared to its active ingredients and vehicle in the treatment of scalp psoriasis: a randomized, double-blind, controlled trial. J Am Acad Dermatol 2008; 59(3):455-63.

Further information: Leo Pharma


Want news like this straight to your inbox?
Sign up for our bulletins

Have you registered with us yet?

Register now to enjoy more articles and free email bulletins

Already registered?
Sign in

More from MIMS

An elderly woman with one arm in a plaster cast sits resting both hands on her walker

Doctors urge NICE to reverse decision on new osteoporosis drug

More than NHS 100 clinicians have called on NICE to...

Drug shortages - live tracker

Use our constantly updated shortages tracker to check...

Image of both strengths of Seffalair Spiromax inhaler side by side.

New salmeterol/fluticasone dry powder inhaler for asthma

Seffalair Spiromax is the sixth dry powder salmeterol/fluticasone...

An older man in a blue shirt and beige trousers leans forward on a sofa rubbing his painful lower back. Promoted

Established muscle relaxant offers new approach to managing back pain

Sponsored by Mibe Pharma

A muscle relaxant that has been used for decades outside the UK may provide an alternative to current treatments for low back pain, explains Dr Sunny Nayee, consultant in anaesthesia and pain medicine at Imperial College NHS Healthcare Trust.

Sponsored by Mibe Pharma UK Ltd. UK/MYO/21/044; December 2021.

Click here to view prescribing information for Myopridin® (pridinol mesilate)