Vildagliptin elderly warnings removed

Vildagliptin was launched in 2008 as the first DPP4 inhibitor | SPL
Vildagliptin was launched in 2008 as the first DPP4 inhibitor | SPL

Prescribing information for vildagliptin (Galvus) and vildagliptin + metformin (Eucreas) no longer includes a cautionary statement about use in the elderly.

The warnings were removed after a pooled analysis of randomised, double-blind trials showed that the dipeptidyl peptidase 4 inhibitor is effective and well tolerated in patients aged 75 years or over with type 2 diabetes.

In this age group (n=25), vildagliptin, as add-on to metformin, was associated with a reduction in HbA1c of 1.1% from a baseline of 8.5% (p=0.0004), with 50% of patients (n=12) achieving an HbA1c of less than 7%. There were no reports of hypoglycaemic events or significant weight gain in elderly patients.

View Galvus drug record

View Eucreas drug record

Further information: Novartis

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