Vfend paediatric dose changed

It is no longer recommended to use a loading dose of the antifungal agent Vfend (voriconazole) when treating children aged 2 to 12 years.

For serious fungal infections in children aged 2 to 12 years the recommended dose is 200 mg (5 ml) Vfend suspension orally twice daily or 7 mg/kg Vfend infusion twice daily or 4mg/kg twice daily if the higher intravenous dose is not tolerated.

Pharmacokinetic data in children and adults indicate that in order to obtain comparable exposures of voriconazole to those in adults a dose of 200 mg of oral suspension twice daily is required in paediatric patients, independent of body weight.

The proportionately higher intravenous dose in children relative to adults reflects the higher elimination capacity in children due to a greater liver mass to body mass ratio.

View Vfend drug record

Further Information: Walton Oaks

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