Treatment Regimens for Eradication of H. pylori (PHE Guidance)

• Check antibiotic history as each additional course of clarithromycin, metronidazole or quinolone increases resistance risk.
• Stress the importance of adherence.
• If diarrhoea develops, consider C. difficile and review need for treatment.
• Seek advice from a gastroenterologist if eradication of H. pylori is not successful with second-line therapy.

 First-line seven-day triple therapy regimens

Second-line seven-day triple therapy regimens

Adapted from: PHE. Test and treat for Helicobacter pylori (HP) in dyspepsia. Quick reference guide for primary care: For consultation and local adaptation (July 2017; updated August 2019)

There are additional dosages and regimens licensed for use in H. pylori eradication; refer to individual SPCs for further information.