Ticagrelor approved for long-term treatment following MI

The antiplatelet treatment Brilique (ticagrelor) can now be prescribed in adults with a history of MI at least one year previously who are at high risk of a further atherothrombotic event.

Ticagrelor is already licensed for the initial prevention of atherothrombotic events following acute coronary syndromes. | iSTOCK
Ticagrelor is already licensed for the initial prevention of atherothrombotic events following acute coronary syndromes. | iSTOCK

The recommended dose of Brilique for patients with a history of MI is 60mg twice daily. A maintenance aspirin dose of 75—150mg should also be taken daily, unless contraindicated.

Reduction in cardiovascular events

Further information
View Brilique drug record
Summary of Product Characteristics
Manufacturer: AstraZeneca 
MIMS Cardiology Clinic

The randomised, double-blind PEGASUS TIMI-54 trial enrolled patients with a history of MI (1 to 3 years prior to randomisation) and at least one additional risk factor for atherothrombosis (n=21,162).

Ticagrelor 60mg twice daily plus low-dose aspirin significantly reduced the primary endpoint of cardiovascular death, MI or stroke at 3 years compared with placebo plus low-dose aspirin (7.77% versus 9.04%; hazard ratio 0.84, 95% CI 0.740.95, p=0.004).

Bleeding risk

Rates of major bleeding were higher with ticagrelor 60mg twice daily plus aspirin than with placebo plus aspirin (2.30% vs 1.06%, p<0.001).

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