Statin/fusidic acid interaction highlighted

Rhabdomyolysis causes the release of damaging myoglobin molecules into the bloodstream | SCIENCE PHOTO LIBRARY
Rhabdomyolysis causes the release of damaging myoglobin molecules into the bloodstream | SCIENCE PHOTO LIBRARY

The MHRA has reminded prescribers of the increased risk of rhabdomyolysis when systemic fusidic acid (Fucidin) is used at the same time as a statin. The exact mechanism of this interaction is unknown and it could therefore occur with some, or all, statins.

The MHRA has issued the following advice:

  • Systemic fusidic acid should not be given with statins.
  • When the use of systemic fusidic acid is essential, statins should be discontinued. They may be restarted 7 days after the last dose of fusidic acid.
  • In exceptional cases requiring prolonged systemic fusidic acid treatment, the need for a statin should be assessed on an individual basis and only undertaken with close medical supervision.
  • Patients should be advised to seek medical advice immediately if they experience muscle weakness, pain or tenderness.
  • Any muscle symptoms reported in patients who are prescribed statins should be followed up.

MHRA Drug Safety Update – September 2011

Want news like this straight to your inbox?
Sign up for our bulletins

Have you registered with us yet?

Register now to enjoy more articles and free email bulletins

Register
Already registered?
Sign in

MIMS Product Slides

Product overviews prepared by the MIMS team, in a handy slide format.

Click here

Slides are initiated, funded & reviewed by the companies specified.

Register or Subscribe to MIMS

GPs can get MIMS print & online and GPonline for free when they register online – take 2 minutes, and make sure you get your free MIMS access! If you're not a GP, you can subscribe to MIMS for full access.

Register or subscribe

MIMS Dermatology

Read the latest issue online exclusively on MIMS Learning.

Read MIMS Dermatology

MIMS Adviser

Especially created for prescribing influencers.

Request free copy

Mobile apps

MIMS: access the full drug database and quick-reference tables on the go

MIMS Diagnosis and Management: concise information on signs and symptoms, investigations and diseases