Second HIV quadruple combination tablet launched

Genvoya is a combination tablet containing elvitegravir, cobicistat, emtricitabine and tenofovir alafenamide, for the treatment of HIV-1 infection. It can be used in patients over 12 years of age and weighing at least 35kg who have no resistance mutations to integrase inhibitors, emtricitabine or tenofovir.

Tenofovir alafenamide is a prodrug of the nucleotide reverse transcriptase inhibitor tenofovir. It is more efficient than tenofovir disoproxil fumarate in concentrating tenofovir in peripheral blood mononuclear cells and macrophages, where HIV-1 replicates.

Further information
View Genvoya drug record
Summary of Product Characteristics
Manufacturer: Gilead Sciences

Elvitegravir, cobicistat and emtricitabine have already been shown to be effective. Elvitegravir is an HIV integrase inhibitor; cobicistat is a cytochrome P450 3A inhibitor that has no anti-HIV activity but acts as a pharmacoenhancer allowing once-daily dosing; and emtricitabine is a nucleoside reverse transcriptase inhibitor.

Low tenofovir dose

The new combination tablet delivers the same antiviral effect as the elvitegravir/cobicistat/emtricitabine/tenofovir disoproxil fumarate tablet (Stribild) but at a lower dose of tenofovir, resulting in reduced drug concentrations in the bloodstream. Studies showed regimens containing tenofovir alafenamide were associated with improvements in laboratory markers of renal and bone safety compared with regimens containing tenofovir disoproxil fumarate.

Genvoya is supplied as 150mg/150mg/200mg/10mg fixed-dose tablets.

Want news like this straight to your inbox?
Sign up for our bulletins

Have you registered with us yet?

Register now to enjoy more articles and free email bulletins

Already registered?
Sign in

MIMS Product Slides

Product overviews prepared by the MIMS team, in a handy slide format.

Click here

Slides are initiated, funded & reviewed by the companies specified.

Register or Subscribe to MIMS

GPs can get MIMS print & online and GPonline for free when they register online – take 2 minutes, and make sure you get your free MIMS access! If you're not a GP, you can subscribe to MIMS for full access.

Register or subscribe

MIMS Dermatology

Read the latest issue online exclusively on MIMS Learning.

Read MIMS Dermatology

MIMS Adviser

Especially created for prescribing influencers.

Request free copy

Mobile apps

MIMS: access the full drug database and quick-reference tables on the go

MIMS Diagnosis and Management: concise information on signs and symptoms, investigations and diseases