It is the first 5HT3 antagonist to be made available in this form.
Patients should apply a single Sancuso patch (releasing granisetron 3.1mg/24 hours) to the upper arm or abdomen 24 to 48 hours before chemotherapy. The patch should be removed a minimum of 24 hours after completion of the chemotherapy but can be worn continuously for up to 7 days.
Non-inferior to oral granisetron
In clinical trials, Sancuso was non-inferior to oral granisetron (2mg once daily) and was generally well tolerated. Constipation was the most commonly reported adverse effect. Mild application site reactions were reported, which did not lead to discontinuation of treatment. If a severe or generalised skin reaction occurs, the patch should be removed.
Further information: ProStrakan