The double-blind SHIFT
study compared ivabradine, the only licensed sinus node If
inhibitor, with placebo in patients with stable chronic heart failure (NHYA class II to IV). Patients were randomised to receive ivabradine 7.5mg twice daily (n=3268) or placebo (n=3290), and were permitted to continue stable background therapy (including β-blockers) if tolerated. Investigators used a composite of cardiovascular death or hospital admission for worsening heart failure as the primary endpoint, and all analyses were based on the intention to treat population.
At the end of the follow-up period (median 22.9 months), fewer patients met the primary endpoint in the ivabradine group (793 events) than in the control group (937 events), resulting in a hazard ratio of 0.82 (95% CI 0.75-0.90; p<0.0001).View Procoralan drug recordFurther information: Servier Laboratories Ltd