Pioglitazone in triple therapy

Previously, Actos was licensed only as monotherapy or as dual therapy in combination with either metformin or a sulphonylurea.

The recommended dose of pioglitazone is the same whether used in montherapy or dual or triple combination therapy. Treatment should be started at 15-30mg once daily increasing to 45mg once daily if necessary in combination with metformin and/or a sulphonylurea.

Common adverse effects associated with triple therapy include weight gain, increased creatine phosphokinase, arthralgia and hypoglycaemia.