Pharmalgen for the Treatment of Bee and Wasp Venom Allergy (TA246)

Technology Appraisal Guidance No. 246

Source: National Institute for Health and Care Excellence

1. Guidance

1.1  Pharmalgen is recommended as an option for the treatment of IgE-mediated bee and wasp venom allergy in people who have had:

  • a severe systemic reaction to bee or wasp venom, or
  • a moderate systemic reaction to bee or wasp venom and who have one or more of the following: a raised baseline serum tryptase, a high risk of future stings or anxiety about future stings.

1.2  Treatment with Pharmalgen should be initiated and monitored in a specialist centre experienced in venom immunotherapy.

The guidance shown above constitutes Section 1 of the full document. A copy of the full document and a summary of the evidence is available on the Internet at

This guidance represents the view of the Institute which was arrived at after careful consideration of the available evidence. Health professionals are expected to fully take it into account when exercising their clinical judgement. This guidance does not, however, override the individual responsibility of health professionals to make appropriate decisions in the circumstances of the individual patient, in consultation with the patient and/or guardian or carer.

© Copyright National Institute for Health and Care Excellence. All rights reserved. This material may be freely reproduced for educational and not for profit purposes within the NHS. No reproduction by or for commercial organisations is permitted without the express written permission of the Institute.

Enquiries concerning the guidance should be addressed to: National Institute for Health and Care Excellence, MidCity Place, 71 High Holborn, London WC1V 6NA.

Pharmalgen for the Treatment of Bee and Wasp Venom Allergy.
Issue Date: February 2012

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