Since paracetamol overdose can lead to serious liver damage, it is also essential to follow the weight-related dose recommendations and to consider individual patient risk factors for hepatotoxicity, including hepatocellular insufficiency, chronic alcoholism, chronic malnutrition and dehydration.
- For children weighing 10kg or less, the dose is 7.5mg/kg (0.75ml/kg) up to 4 times daily and the volume of Perfalgan administered should never exceed 7.5ml per dose. Smaller volumes will be required with lower weights.
- For children and adults weighing 33–50kg, the dose is 15mg/kg (1.5ml/kg) up to 4 times daily (max 3g/24 hours) and the volume of Perfalgan administered should never exceed 75ml per dose.
Further information: Bristol-Myers Squibb Pharmaceuticals Ltd