Perfalgan overdose warning

To avoid accidental overdose with Perfalgan (paracetamol) 10mg/ml solution for infusion, prescribers are recommended to specify the volume of administration in ml.

Polarised light micrograph of paracetamol crystals | SCIENCE PHOTO LIBRARY
Polarised light micrograph of paracetamol crystals | SCIENCE PHOTO LIBRARY

Since paracetamol overdose can lead to serious liver damage, it is also essential to follow the weight-related dose recommendations and to consider individual patient risk factors for hepatotoxicity, including hepatocellular insufficiency, chronic alcoholism, chronic malnutrition and dehydration.

Recommended doses

  • For children weighing 10kg or less, the dose is 7.5mg/kg (0.75ml/kg) up to 4 times daily and the volume of Perfalgan administered should never exceed 7.5ml per dose. Smaller volumes will be required with lower weights. 
  • For children and adults weighing 33–50kg, the dose is 15mg/kg (1.5ml/kg) up to 4 times daily (max 3g/24 hours) and the volume of Perfalgan administered should never exceed 75ml per dose.

View Perfalgan drug record

Further information: Bristol-Myers Squibb Pharmaceuticals Ltd

Want news like this straight to your inbox?
Sign up for our bulletins

Have you registered with us yet?

Register now to enjoy more articles and free email bulletins

Register
Already registered?
Sign in

More from MIMS

Drug shortages - live tracker

Use our constantly updated shortages tracker to check...

Logo of the webinar

Cow's Milk Allergy in Practice: free webinar series for UK healthcare professionals

Join us for a short webinar series offering insights...

Close up image of multicoloured capsules

MIMS antidepressants table updated

The MIMS table 'Antidepressants, a guide to switching...

Purple, orange, blue and yellow blood test tubes on a tray.

New advice on vitamin B12 monitoring in patients taking metformin

Patients on metformin treatment with risk factors for...