Panitumumab in Combination with Chemotherapy for the Treatment of Metastatic Colorectal Cancer (terminated appraisal) (TA240)

Technology Appraisal Guidance No. 240

Source: National Institute for Health and Care Excellence

NICE is unable to recommend panitumumab with 5-fluorouracil, folinic acid and irinotecan (FOLFIRI) for previously treated metastatic colorectal cancer in adults because no evidence submission was received from the manufacturer or sponsor of the technology.

We have published guidance on cetuximab and panitumumab for previously untreated metastatic colorectal cancer.

Since the publication of TA240, the population covered by the marketing authorisation for panitumumab has changed from ‘patients with wild-type KRAS metastatic colorectal cancer’ to ‘patients with wild-type RAS metastatic colorectal cancer’.

A copy of the full document and background is available on the Internet at

This guidance represents the view of the Institute which was arrived at after careful consideration of the available evidence. Health professionals are expected to fully take it into account when exercising their clinical judgement. This guidance does not, however, override the individual responsibility of health professionals to make appropriate decisions in the circumstances of the individual patient, in consultation with the patient and/or guardian or carer.

© Copyright National Institute for Health and Care Excellence. All rights reserved. This material may be freely reproduced for educational and not for profit purposes within the NHS. No reproduction by or for commercial organisations is permitted without the express written permission of the Institute.

Enquiries concerning the guidance should be addressed to: National Institute for Health and Care Excellence, MidCity Place, 71 High Holborn, London WC1V 6NA.

Panitumumab in combination with chemotherapy for the treatment of metastatic colorectal cancer (terminated appraisal).
Issue Date: December 2011 (Updated March 2017)

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