Ozurdex recommended for uveitis

The intravitreal implant formulation of dexamethasone (Ozurdex) has had its licence extended to include the treatment of non-infectious uveitis in adults.

In a single, multicentre, masked study, 229 patients with non-infectious intermediate or posterior uveitis were randomised to receive a single 700 microgram or 350 microgram dexamethasone implant or sham, via intravitreal injection.

The proportion of eyes with a vitreous haze score of 0 was 47% for the 700 microgram implant and 36% for the 350 microgram implant and 12% for the sham injection (p<0.001 for both comparisons). This statistically significant difference continued until the end of the study (Week 26). The reduction in visual haze was accompanied by a baseline best-corrected visual acuity improvement of ≥15 letters in the respective treatment groups.

There is currently no experience of repeat administration for this indication.

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