Nicorandil and GI ulceration

Nicorandil (Ikorel), indicated for the prevention and treatment of angina, is associated with a risk of gastrointestinal ulceration, including perianal ulceration, according to a recent safety update from the MHRA.

Mouth ulceration has long been a recognised adverse effect of nicorandil, however healthcare professionals should now consider nicorandil treatment as a possible cause in patients with symptoms of gastrointestinal ulceration.

The ulceration can be severe and, in a few patients, has led to perforation. Ulcers are refractory to treatment and only respond to withdrawal of nicorandil. Withdrawal should take place only under the supervision of a cardiologist.

Further information: MHRA

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