NICE approves reslizumab for severe eosinophilic asthma

NICE has approved the use of reslizumab (Cinqaero) as an add-on therapy for the treatment of inadequately controlled severe eosinophilic asthma.

Treatment options for people with severe asthma are limited. | STEVE GSCHMEISSNER/SCIENCE PHOTO LIBRARY
Treatment options for people with severe asthma are limited. | STEVE GSCHMEISSNER/SCIENCE PHOTO LIBRARY

Reslizumab is licensed as an add-on treatment for severe eosinophilic asthma that is inadequately controlled in adults despite maintenance therapy with high-dose inhaled corticosteroids plus another maintenance treatment.

The NICE guidance states that adults are eligible for treatment only if their blood eosinophil count is ≥400 cells per microlitre and the patient has had 3 or more asthma exacerbations requiring systemic corticosteroids in the previous 12 months.

'Reslizumab has the potential to dramatically improve the quality of life for some people living with severe asthma and we are delighted that it has been recommended for use on the NHS,' said Kay Boycott, Chief Executive of Asthma UK.

'New monoclonal antibody treatments, which have shown success in clinical trials. are likely to be effective in treating around 30-40% of those living with severe asthma, so it is imperative that they are made available,' she added.

Review after 12 months

Treatment with reslizumab should be reviewed after 12 months and stopped if there has been an inadequate response. If the response at 12 months is adequate, treatment may be continued with an annual assessment of response thereafter.

An adequate response is defined as clinically meaningful reduction in the number of severe exacerbations requiring systemic corticosteroids or a clinically significant reduction in continuous oral corticosteroid use while maintaining or improving asthma control.

Approval of reslizumab by NICE is contingent on the manufacturer supplying the monoclonal antibody with the discount agreed in the patient access scheme.

Want news like this straight to your inbox?
Sign up for our bulletins

Read these next

Pictorial inhaler guide published on MIMS website

Pictorial inhaler guide published on MIMS website

Images and key features of inhalers and other respiratory...

Asthma and COPD Preparations and Compatible Devices

Asthma and COPD Preparations and Compatible Devices

Available presentations of bronchodilators and anti-inflammatories.

NICE approves mepolizumab for refractory eosinophilic asthma

NICE approves mepolizumab for refractory eosinophilic asthma

Mepolizumab may be used within the NHS for the treatment...


Have you registered with us yet?

Register now to enjoy more articles and free email bulletins

Register
Already registered?
Sign in

MIMS Product Slides

Product overviews prepared by the MIMS team, in a handy slide format.

Click here

Slides are initiated, funded & reviewed by the companies specified.

Register or Subscribe to MIMS

GPs can get MIMS print & online and GPonline for free when they register online – take 2 minutes, and make sure you get your free MIMS access! If you're not a GP, you can subscribe to MIMS for full access.

Register or subscribe

MIMS Dermatology

Read the latest issue online exclusively on MIMS Learning.

Read MIMS Dermatology

MIMS Adviser

Especially created for prescribing influencers.

Request free copy

Mobile apps

MIMS: access the full drug database and quick-reference tables on the go

MIMS Diagnosis and Management: concise information on signs and symptoms, investigations and diseases