New pulmonary arterial hypertension treatment

Encysive has launched Thelin (sitaxentan) for the treatment of pulmonary arterial hypertension (WHO class III) to improve exercise capacity.

PHARMACOLOGY
Sitaxentan is a highly selective enothelin-A (ETA) receptor antagonist. These receptors are found on smooth muscle cells and facilitate vasoconstriction.

CLINICAL STUDIES
The efficacy of sitaxentan has been studied in two randomised, double-blind trials, STRIDE-1 and STRIDE-2 (Sitaxentan To Relieve Impaired Exercise).

STRIDE-1 enrolled 178 patients1 with moderate to severe (WHO class II-IV) pulmonary arterial hypertension (PAH) resulting from idiopathic PAH, connective tissue disease or congenital heart disease. Patients received placebo, sitaxentan 100mg or sitaxentan 300mg once daily for 12 weeks.

After 12 weeks the sitaxentan treatment groups showed significant benefit in six-minute walk (6MW) distance, WHO functional class and haemodynamic parameters compared to the placebo group.

STRIDE-2 aimed to determine the optimal dose of sitaxentan for the treatment of PAH. The study2 enrolled 247 patients, randomised to receive placebo, sitaxentan 50mg or 100mg once daily, or open label bosentan for 18 weeks (the bosentan group was included for observation only).

At week 18, the greatest increase in 6MW distance was observed in the sitaxentan 100mg group, followed by the bosentan group, then the sitaxentan 50mg group. The sitaxentan 100mg group also showed an improved WHO functional class.

1. Langleben D, Brock T, Dixon R et al. STRIDE 1: Effects of the selective ETA receptor antagonist, sitaxsentan sodium, in a patient population with pulmonary arterial hypertension that meets tradional inclusion criteria of previous pulmonary arterial hypertension trials. J Cardiovasc Pharmacol 2004, Suppl.1: S80-84.
2. Barst R, Langleben D, Badesch D et al. Treatment of pulmonary arterial hypertension with the selective enothelin-A receptor antagonist sitaxsenstan. JACC 2006 (47): 2049-56.

Further information: Encysive 0800 0121241

Want news like this straight to your inbox?
Sign up for our bulletins

Have you registered with us yet?

Register now to enjoy more articles and free email bulletins

Register
Already registered?
Sign in

MIMS Product Slides

Product overviews prepared by the MIMS team, in a handy slide format.

Click here

Slides are initiated, funded & reviewed by the companies specified.

MIMS Dermatology

Read the latest issue online exclusively on MIMS Learning.

Read MIMS Dermatology

MIMS app

Access the full drug database and quick-reference tables on the go

Find out more