New interaction warnings for simvastatin

New contraindications have been issued for simvastatin.

Grapefruit juice should be avoided when taking simvastatin. SCIENCE PHOTO LIBRARY
Grapefruit juice should be avoided when taking simvastatin. SCIENCE PHOTO LIBRARY

The statin is now contraindicated for use in combination with ciclosporin, danazol and gemfibrozil, the MHRA has advised. In addition, the agency has recommended a new maximum dose of 20mg per day for simvastatin when used in conjunction with amlodipine or diltiazem.

The recommendations take into account the potential for increased plasma concentrations of simvastatin when used concomitantly with these medicines, resulting in an increased risk of myopathy and/or rhabdomyolysis.

Other medicines contraindicated for use with simvastatin include azole antifungals, macrolide antibiotics and HIV protease inhibitors. Dose restrictions for simvastatin also apply during concomitant use with amiodarone and verapamil (maximum 20mg daily) and other fibrates (except for fenofibrate, maximum 10mg daily).

View simvastatin drug record

Further information: MHRA

Follow MIMS on Twitter

Want news like this straight to your inbox?
Sign up for our bulletins

Have you registered with us yet?

Register now to enjoy more articles and free email bulletins

Register
Already registered?
Sign in

MIMS app

Access the full drug database and quick-reference tables on the go

Find out more