New indication for Tyverb

Tyverb (lapatinib) has had its licence extended to include use in combination with an aromatase inhibitor (AI), for the first-line treatment of post-menopausal women with hormone receptor (HR)-positive, ErbB2 (HER2)-overexpressing metastatic breast cancer for whom chemotherapy is not currently intended.

The registration trial showed that there was a significant improvement in progression-free survival (PFS) in patients overexpressing ErbB2 when both ErbB2 and HR receptors were targeted with lapatinib in combination with letrozole (an AI), with patients given lapatinib plus letrozole experiencing a median PFS of 8.2 months and patients given placebo plus letrozole experiencing a median PFS of 3 months.

View Tyverb drug record

Further information: GlaxoSmithKline

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