New contraindication for AstraZeneca COVID-19 vaccine

The AstraZeneca COVID-19 vaccine, now known as Vaxzevria, should not be given to people with a history of capillary leak syndrome.

Patients with a history of capillary leak syndrome should not be vaccinated with Vaxzevria. | GETTY IMAGES
Patients with a history of capillary leak syndrome should not be vaccinated with Vaxzevria. | GETTY IMAGES

According to the updated prescribing information for Vaxzevria, very rare cases of capillary leak syndrome have been reported in the first days after receiving the vaccine. A history of capillary leak syndrome was apparent in some of the cases, a number of which were fatal. The vaccine should therefore not be given to individuals with a history of the condition.

Capillary leak syndrome is a rare disorder characterised by acute episodes of oedema mainly affecting the limbs, hypotension, haemoconcentration and hypoalbuminaemia. Patients with an acute episode following vaccination require prompt recognition and treatment, and intensive supportive therapy is usually warranted.

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