Epiduo (adapalene 0.1% + benzoyl peroxide 2.5%) is a new anti-acne gel containing two agents with complementary mechanisms of action.
Adapalene (Differin) is thought to modulate cellular differentiation and keratinisation; it also has anti-inflammatory activity. Benzoyl peroxide has ketatolytic, exfoliative, sebostatic and antimicrobial properties.
Two 12-week, randomised, double-blind studies of Epiduo were conducted in a total of 2185 patients. The gel produced greater reductions in lesion counts and had higher success rates (proportion of patients rated ‘clear' or ‘almost clear') than either of the active components alone, or placebo (gel vehicle).
Further information: Galderma