Lennox-Gastaut syndrome is a severe form of epilepsy, characterised by onset in early childhood of frequent seizures of multiple types.
Rufinamide is a broad-spectrum anticonvulsant that is structurally distinct from other antiepileptic drugs. It modulates the activity of neuronal sodium channels, prolonging their inactive state. Efficacy against seizures of Lennox-Gastaut syndrome has been demonstrated.
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