Moxifloxacin is a fourth-generation fluoroquinolone antibiotic. It inhibits enzymes required for bacterial DNA replication, repair and recombination.1
In vitro tests were carried out to compare the activity of moxifloxacin, gatifloxacin, levofloxacin, ofloxacin and ciprofloxacin against 93 bacterial endophthalmitis isolates. Moxifloxacin was the most potent agent against Gram positive bacteria (p=0.05). It had equivalent potency to ciprofloxacin, gatifloxacin and levofloxacin against Gram negative bacteria.2
Commonly susceptible organisms include Corynebacterium species (including Corynebacterium diphtheriae), Staphylococcus aureus, Streptococcus species (including pneumoniae, pyogenes and viridans group), Enterobacter cloacae, Haemophilus influenza, Klebsiella oxytoca, Moraxella catarrhalis, Serratia marcescens, Propionibacterium acnes and Chlamydia trachomatis.
Cross-resistance of moxifloxacin with beta-lactams, macrolides and aminoglycosides is not expected. However, cross-resistance with other fluoroquinolones has been observed.3 Moxivig should not be used for the prophylaxis or empiric treatment of gonococcal conjunctivitis, because of the prevalence of fluoroquinolone-resistant Neisseria gonorrhoeae.1
- Moxivig Summary of Product Characteristics, March 2010.
- Mather R et al. Am J Ophthalmol 2002; 133: 463-6.
- Miller D. Clin Ophthalmol 2008; 2: 77–91.
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