Nevanac (nepafenac) is a topical NSAID for use in preventing and managing post-operative pain. Nepafenac is a prodrug, it penetrates the cornea and is converted to its active metabolite amfenac. Amfenac then inhibits the action of cyclooxygenase thereby inhibiting prostaglandin production.
Treatment should be started on the day before cataract surgery and continued for up to three weeks after surgery. Drops should be applied to the affected eye(s) three times daily with an additional drop 30-120 minutes prior to surgery.
As with other NSAIDs, nepafenac is contraindicated in patients in whom attacks of asthma, urticaria or acute rhinitis are precipitated by acetylsalicylic acid or other NSAIDS.
Further information: Alcon