In respiratory use, patients with a history of heart disease, including angina or rhythm disturbance, should be advised to continue treatment with short-acting beta-agonists, but to seek advice if symptoms such as shortness of breath or chest pain occur.
In women with significant risk factors for — or who have pre-existing ischaemic heart disease — the risk of myocardial ischaemia outweighs the benefits of use of short-acting beta-agonists such as ritodrine, salbutamol, or terbutaline for the prevention of premature labour. Other treatments (e.g. atosiban) do not carry a similar risk.
In all other patients, short-acting beta-agonists should be used with caution in the prevention of premature labour because of the risk of myocardial ischaemia
Further information: MHRA