Mozobil

Plerixafor in combination with G-CSF to enhance mobilisation of haematopoietic stem cells to peripheral blood for collection and autologous transfusion in patients with lymphoma or multiple myeloma.

Plerixafor reversibly blocks the chemokine receptor CXCR4 to prevent binding of its ligand CXCL12 (stromal cell-derived factor-1α).

The drug is injected after four days of treatment with granulocyte-colony stimulating factor (G-CSF), 6-11 hours before initiation of apheresis. Following administration, both haematopoietic progenitor cells and mature leukocytes appear in the systemic circulation.

View Mozobil drug record

Further information: Genzyme

Want news like this straight to your inbox?
Sign up for our bulletins

Have you registered with us yet?

Register now to enjoy more articles and free email bulletins

Register
Already registered?
Sign in

MIMS app

Access the full drug database and quick-reference tables on the go

Find out more