MHRA updates warfarin safety advice

Safety issues surrounding the use of warfarin have been reviewed by the MHRA.

As detailed in the agency's Public Assessment Report, the drug's contraindications have been tightened to include use within 72 hours of surgery or 48 hours of labour.

Active peptic ulcer, risk factors for haemorrhage and thyroid disorders are listed amongst the circumstances in which use of warfarin requires caution.

The list of potential drug interactions has been updated and liver dysfunction has been added as a potential adverse effect.

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