Lantus licence extended to include children 2 years and older

Lantus (insulin glargine) has been licensed for use in children aged two years and above with diabetes mellitus.

A clinical study found no evidence of accumulation of insulin glargine (a long-acting analogue of human insulin, pictured) or its metabolites following chronic dosing in children aged 2 to 6 years
A clinical study found no evidence of accumulation of insulin glargine (a long-acting analogue of human insulin, pictured) or its metabolites following chronic dosing in children aged 2 to 6 years

The dosage schedule for the long-acting insulin analogue is the same as for adults and children aged 6 years and over: one subcutaneous injection at the same time each day with the number of units determined by individual patient requirements.

Clinical study

A 24-week parallel-group study recruited 125 children aged 2—6 years with type 1 diabetes mellitus. Children were administered either insulin glargine once daily in the morning or NPH insulin once or twice daily. In addition, both groups received bolus insulin before meals.

Plasma trough concentrations of insulin glargine were similar to those normally seen in adults, and HbA1c and glucose variabilities were comparable in the two treatment groups. However, non-inferiority of insulin glargine to NPH in terms of hypoglycaemic events was not demonstrated and researchers noted a trend towards an increase in hypoglycaemic events with insulin glargine.

View Lantus drug record

Further information: Sanofi

Follow MIMS on Twitter

Want news like this straight to your inbox?
Sign up for our bulletins

Have you registered with us yet?

Register now to enjoy more articles and free email bulletins

Register
Already registered?
Sign in

More from MIMS

Gluten-free prescribing restricted to bread and mixes

Gluten-free prescribing restricted to bread and mixes

GPs in England are no longer able to prescribe gluten-free...

New vitamin D deficiency thresholds recommended

New vitamin D deficiency thresholds recommended

The National Osteoporosis Society (NOS) has updated...

SGLT2 inhibitors associated with increased risk of lower-limb amputation in new study

SGLT2 inhibitors associated with increased risk of lower-limb amputation in new study

SGLT2 inhibitors may be linked to a doubling in the...

New MIMS table helps prescribers choose asthma inhalers

New MIMS table helps prescribers choose asthma inhalers

Prescribers can now turn to a handy MIMS comparison...