Jetrea: first pharmacological treatment for vitreomacular adhesion

Jetrea (ocriplasmin) is an intravitreal injection for the treatment of vitreomacular traction (VMT), including that associated with macular holes of up to 400 microns diameter.

Treatment with Jetrea in the other eye is not recommended concurrently or within 7 days of the initial injection.
Treatment with Jetrea in the other eye is not recommended concurrently or within 7 days of the initial injection.

PHARMACOLOGY

Ocriplasmin is a truncated form of human plasmin. It has a proteolytic effect on numerous components of the vitreous body and vitreoretinal interface, including collagen, fibronectin and laminin. It is the abnormal binding of these proteins that can result in vitreomacular adhesion (VMA), leading to VMT.

CLINICAL STUDIES

The safety and efficacy of ocriplasmin was evaluated in two multicentre, randomised, double-blind, phase III studies involving 652 adults with VMT. In an analysis of the combined results, the incidence of VMA resolution at day 28 was significantly higher in patients treated with ocriplasmin than in those given placebo (26.5% vs 10.1%, p<0.001).2

With regard to secondary endpoints, total posterior vitreous detachment at day 28 was more common in the ocriplasmin group than in the placebo group (13.4% vs. 3.7%, p<0.001). Non-surgical closure of macular holes was achieved in 40.6% of ocriplasmin-injected eyes, compared with 10.6% of placebo-injected eyes (p<0.001).2 

References:

  1. Jetrea Summary of Product Characteristics, March 2013.
  2. Stalmans P et al. N Engl J Med 2012; 367: 606–15. 

View Jetrea drug record

Further information: Alcon Laboratories

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