Inhaled Corticosteroids for the Treatment of Chronic Asthma in Children Under the Age of 12 Years (TA131)

Technology Appraisal Guidance No. 131

Source: National Institute for Health and Care Excellence

1. Guidance

This guidance should be read in conjunction with Inhaler devices for routine treatment of chronic asthma in older children (aged 5-15 years), NICE technology appraisal guidance 38, and Guidance on the use of inhaler systems (devices) in children under the age of 5 years with chronic asthma, NICE technology appraisal guidance 10. The future discontinuation of CFCcontaining inhaler devices will affect the range of devices available but does not affect the guidance.

1.1 For children under the age of 12 years with chronic asthma in whom treatment with an inhaled corticosteroid (ICS) is considered appropriate, the least costly product that is suitable for an individual child (taking into consideration technology appraisal guidance 38 and 10), within its marketing authorisation, is recommended.

1.2 For children under the age of 12 years with chronic asthma in whom treatment with an ICS and long-acting beta-2 agonist (LABA) is considered appropriate, the following apply.

  • The use of a combination device within its marketing authorisation is recommended as an option.
  • The decision to use a combination device or the two agents in separate devices should be made on an individual basis, taking into consideration therapeutic need and the likelihood of treatment adherence.
  • If a combination device is chosen then the least costly device that is suitable for the individual child is recommended.

The guidance shown above constitutes Section 1 of the full document. A copy of the full document and a summary of the evidence is available on the Internet at

An abridged version of this guidance (a 'quick reference guide') is also available. Printed copies of the quick reference guide can be obtained by contacting 0845 003 7783 or emailing and quoting reference number N1400. It is also available on the Internet at

This guidance represents the view of the Institute which was arrived at after careful consideration of the available evidence. Health professionals are expected to fully take it into account when exercising their clinical judgement. This guidance does not, however, override the individual responsibility of health professionals to make appropriate decisions in the circumstances of the individual patient, in consultation with the patient and/or guardian or carer.

© Copyright National Institute for Health and Care Excellence. All rights reserved. This material may be freely reproduced for educational and not for profit purposes within the NHS. No reproduction by or for commercial organisations is permitted without the express written permission of the Institute.

Enquiries concerning the guidance should be addressed to: National Institute for Health and Care Excellence, MidCity Place, 71 High Holborn, London WC1V 6NA. email:

Inhaled Corticosteroids for the Treatment of Chronic Asthma in Children Under the Age of 12 Years
Issue Date: November 2007
Review Date: November 2012

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