Imatinib for the Treatment of Unresectable and/or Metastatic Gastrointestinal Stromal Tumours (TA209 [Part Review of TA86])

Technology Appraisal Guidance No. 209

Source: National Institute for Health and Care Excellence

This guidance should be read in conjunction with NICE technology appraisal guidance 86 (TA86) ‘Imatinib for the treatment of unresectable and/or metastatic gastrointestinal stromal tumours’.

This guidance updates recommendation 1.4 of TA86. All other recommendations in TA86 still stand.

1. Guidance


1.1 Imatinib at 600 or 800 mg/day is not recommended for people with unresectable and/or metastatic gastrointestinal stromal tumours whose disease has progressed after treatment with 400 mg/day imatinib.

1.2 People who are currently receiving 600 or 800 mg/day imatinib for unresectable and/or metastatic gastrointestinal stromal tumours should have the option to continue therapy until they and their clinicians consider it appropriate to stop.


The guidance shown above constitutes Section 1 of the full document. A copy of the full document and a summary of the evidence is available on the Internet at http://www.nice.org.uk/guidance/index.jsp?action=byID&o=13280

An abridged version of this guidance (a 'quick reference guide') is also available. Printed copies of the quick reference guide can be obtained by contacting 0845 003 7783 or emailing publications@nice.org.uk and quoting reference number N2365. It is also available on the Internet at http://guidance.nice.org.uk/TA209/QuickRefGuide/pdf/English.

This guidance represents the view of the Institute which was arrived at after careful consideration of the available evidence. Health professionals are expected to fully take it into account when exercising their clinical judgement. This guidance does not, however, override the individual responsibility of health professionals to make appropriate decisions in the circumstances of the individual patient, in consultation with the patient and/or guardian or carer.

© Copyright National Institute for Health and Care Excellence. All rights reserved. This material may be freely reproduced for educational and not for profit purposes within the NHS. No reproduction by or for commercial organisations is permitted without the express written permission of the Institute.

Enquiries concerning the guidance should be addressed to: National Institute for Health and Care Excellence, MidCity Place, 71 High Holborn, London WC1V 6NA. email: nice@nice.nhs.uk

Imatinib for the Treatment of Unresectable and/or Metastatic Gastro-intestinal Stromal Tumours: Part Review of NICE Technology Appraisal Guidance 86
Issue Date: November 2010
Review Date:


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