Excess mortality with erythropoietins

The MHRA has asked manufacturers of recombinant human erythropoietins (r-HeEPOs) to update their safety advice, following publication of data showing a consistent, unexplained excess mortality in patients with anaemia associated with cancer.

In addition, studies suggest that treatment of anaemia with r-HeEPOs in patients with chronic kidney disease to achieve relatively high target haemoglobin levels may be associated with an increased risk of mortality and cardiovascular morbidity.

The new advice outlines changes to dose recommendations, including, where necessary, to stipulate a uniform target haemoglobin concentration range of 10—12 g/dL. Haemoglobin levels higher than 12g/dL should be avoided

Further information: MHRA

Want news like this straight to your inbox?
Sign up for our bulletins

Have you registered with us yet?

Register now to enjoy more articles and free email bulletins

Register
Already registered?
Sign in

More from MIMS

Emollients, Potential Skin Sensitisers as Ingredients

Emollients, Potential Skin Sensitisers as Ingredients

Potential sensitising agents in emollient preparations.

Ophthalmic Preparations, Preservatives and Potential Sensitisers as Ingredients

Ophthalmic Preparations, Preservatives and Potential Sensitisers as Ingredients

Potential sensitising agents in eye drops and ointments.

Anti-Anginal Preparations, Summary by Pharmacological Class

Anti-Anginal Preparations, Summary by Pharmacological Class

Available formulations of anti-anginal drugs.

Researchers query safety of delaying antibiotics for UTI in elderly

Researchers query safety of delaying antibiotics for UTI in elderly

Delaying or withholding antibiotics for symptoms of...