EMA: "small increased risk of bladder cancer" with pioglitazone

In patients who respond to pioglitazone, the CHMP concluded that the benefits outweigh the risks | SCIENCE PHOTO LIBRARY
In patients who respond to pioglitazone, the CHMP concluded that the benefits outweigh the risks | SCIENCE PHOTO LIBRARY

A review into the possible increased risk of bladder cancer with pioglitazone has been completed by the MHRA. The results indicated that there is a small increase in risk associated with pioglitazone use.

As a result, pioglitazone is contraindicated in patients with active or historical bladder cancer, or uninvestigated haematuria and all patients should be assessed for risk factors. These include:

  • age
  • current or history of smoking
  • previous pelvic irradiation
  • exposure to certain occupational or chemotherapy agents, for example cyclophosphamide.

Additionally, treatment in the elderly should be carefully considered due to their increased risk of bladder cancer.

In patients who are prescribed pioglitazone, the risk-benefit should be considered after 3–6 months and patients swapped to other treatment (if appropriate).

Two pioglitazone-containing products are available in the UK: pioglitazone alone (Actos) and pioglitazone plus metformin (Competact).

Want news like this straight to your inbox?
Sign up for our bulletins

Have you registered with us yet?

Register now to enjoy more articles and free email bulletins

Register
Already registered?
Sign in

More from MIMS

Soft-mist inhaler now available as reusable device

Soft-mist inhaler now available as reusable device

Respimat is now available as a reusable inhaler that...

NICE recommends 'innovative' treatment for type I diabetes

NICE recommends 'innovative' treatment for type I diabetes

Dapagliflozin (Forxiga) has been approved for routine...

Drug shortages - live tracker

Drug shortages - live tracker

Added: Elleste Duet, Elleste Solo, Diprosone and Livial.

Potentially addictive medicines 'being prescribed for years'

Potentially addictive medicines 'being prescribed for years'

Hundreds of thousands of people are receiving prescriptions...