New dosing recommendations
Based on these results, in combination with data from additional phase I and II trials using a 1g dosing regimen and from the pivotal phase III studies that used the 500mg dose, the following recommendations have been made:
- The usual treatment duration for nosocomial pneumonia (including VAP) should be 10–14 days, preferably 14 days in infections due to non-fermenting organisms (eg, Pseudomonas or Acinetobacter spp.).
- A dose of 1g by intravenous infusion over four hours at 8-hourly intervals should be considered if the patient has creatinine clearance ≥150ml/min or if infection is due to non-fermenting organisms.
- Caution should be exercised when choosing doripenem as treatment, taking into account the appropriateness of a carbapenem antibacterial based on severity of infection, prevalence of resistance to other suitable antibacterials and the risk of selecting for carbapenem-resistant bacteria.
- Consideration should be used when giving concomitant aminoglycosides (for example, if co-infection with P. aeruginosa is suspected or proven).
Further information: Janssen-Cilag Ltd