Daclizumab for Treating Relapsing-Remitting Multiple Sclerosis (TA441)

Technology Appraisal Guidance No. 441

Source: National Institute for Health and Care Excellence

1. Guidance

1.1  Daclizumab is recommended as an option for treating multiple sclerosis in adults, only if:

  • the person has active relapsing–remitting multiple sclerosis previously treated with disease-modifying therapy, or rapidly evolving severe relapsing–remitting multiple sclerosis (that is, at least 2 relapses in the previous year and at least 1 gadolinium-enhancing lesion at baseline MRI) and
  • alemtuzumab is contraindicated or otherwise unsuitable and
  • the company provides the drug with the discount agreed in the patient access scheme.

1.2 This guidance is not intended to affect the position of patients whose treatment with daclizumab was started within the NHS before this guidance was published. Treatment of those patients may continue without change to whatever funding arrangements were in place for them before this guidance was published until they and their NHS clinician consider it appropriate to stop.

A copy of the full document and background is available on the Internet at http://guidance.nice.org.uk/TA441

This guidance represents the view of the Institute which was arrived at after careful consideration of the available evidence. Health professionals are expected to fully take it into account when exercising their clinical judgement. This guidance does not, however, override the individual responsibility of health professionals to make appropriate decisions in the circumstances of the individual patient, in consultation with the patient and/or guardian or carer.

© Copyright National Institute for Health and Care Excellence. All rights reserved. This material may be freely reproduced for educational and not for profit purposes within the NHS. No reproduction by or for commercial organisations is permitted without the express written permission of the Institute.

Enquiries concerning the guidance should be addressed to: National Institute for Health and Care Excellence, MidCity Place, 71 High Holborn, London WC1V 6NA. email:nice@nice.org.uk

Daclizumab for treating relapsing–remitting multiple sclerosis.
Issue Date: April 2017

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