Coversyl shown to reduce mortality rate

The ACE inhibitor Coversyl (perindopril) has been approved for the treatment of stable coronary artery disease to reduce the risk of cardiac events in patients with a history of myocardial infarction and/or revascularisation.

The change to the licensed indications for Coversyl was made on the basis of results from a major, four-year, double-blind study involving over 12,000 patients with stable coronary artery disease and without heart failure or substantial hypertension.

The study showed that Coversyl 8 mg once daily reduced the combined risk of cardiovascular mortality, non-fatal myocardial infarction and cardiac arrest. The benefits were obtained on top of other preventative medications such as anti-platelet agents, lipid- lowering drugs and ß-blockers, and were consistent for all coronary artery disease patients irrespective of age or other cardiac risk factors.

For adults with stable coronary artery disease, treatment should be initiated at a dose of 4 mg once daily for two weeks, before increasing to 8 mg once daily.

In elderly patients, the dose should be started at 2 mg once daily, increasing after one week to 4 mg once daily for the next week, before increasing to 8 mg once daily.

In all patients, dose titration is dependent upon tolerance and renal function.

Further information: Servier Laboratories Ltd, Gallions, Wexham Springs, Framewood Road, Slough, Berks, SL3 6RJ. Tel: 01753 662744.

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