Dovobet Gel is a combined preparation of calcipotriol and betamethasone (50/500 microgram per gram), licensed for both scalp and body psoriasis. It is presented as a clear, alcohol-free gel.
Calcipotriol and betamethasone have complementary mechanisms of action in the treatment of psoriasis. Calcipotriol, a vitamin D analogue, is thought to inhibit keratinocyte proliferation; betamethasone, a corticosteroid, acts as an anti-inflammatory.
The combination gel was tested in randomised, double-blind studies in patients with body psoriasis (n=364) or scalp psoriasis (n=1,505). Response rates observed after the recommended duration of treatment (eight and four weeks, respectively) were significantly higher for the combination gel than for the calcipotriol, betamethasone or vehicle gels alone.
Further information: Leo Pharma