Capecitabine and Oxaliplatin in the Adjuvant Treatment of Stage III (Dukes' C) Colon Cancer (TA100)

Technology Appraisal Guidance No. 100

Source: National Institute for Health and Care Excellence

1. Guidance

1.1 The following are recommended as options for the adjuvant treatment of patients with stage III (Dukes' C) colon cancer following surgery for the condition:

  • capecitabine as monotherapy
  • oxaliplatin in combination with 5-fluorouracil and folinic acid.

1.2 The choice of adjuvant treatment should be made jointly by the individual and the clinicians responsible for treatment. The decision should be made after an informed discussion between the clinicians and the patient; this discussion should take into account contraindications and the side-effect profile of the agent(s) and the method of administration as well as the clinical condition and preferences of the individual.

The guidance shown above constitutes Section 1 of the full document. A copy of the full document and a summary of the evidence is available on the Internet at

Copies of the document can be obtained by contacting 0845 003 7783 or emailing and quoting reference number N1026.

This guidance represents the view of the Institute which was arrived at after careful consideration of the available evidence. Health professionals are expected to fully take it into account when exercising their clinical judgement. This guidance does not, however, override the individual responsibility of health professionals to make appropriate decisions in the circumstances of the individual patient, in consultation with the patient and/or guardian or carer.

© Copyright National Institute for Health and Care Excellence. All rights reserved. This material may be freely reproduced for educational and not for profit purposes within the NHS. No reproduction by or for commercial organisations is permitted without the express written permission of the Institute.

Enquiries concerning the guidance should be addressed to: National Institute for Health and Care Excellence, MidCity Place, 71 High Holborn, London WC1V 6NA. email:

Capecitabine and Oxaliplatin in the Adjuvant Treatment of Stage III (Dukes' C) Colon Cancer.
Issue Date: April 2006
Review Date: June 2009

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