Arzerra: new leukaemia antibody

GlaxoSmithKline has launched a new biological treatment for chronic lymphocytic leukaemia (CLL).

Ofatumumab (Arzerra) is a fully human monoclonal antibody. Like rituximab, it is specific for the CD20 antigen found on B cells.

Ofatumumab was tested in a pivotal study in 154 patients with CLL, a type of B cell tumour. Among the 59 participants who were refractory to fludarabine and alemtuzumab, 58% responded to ofatumumab treatment. Response rates were comparable between those who had previously received rituximab and those who had not.

Arzerra has been conditionally approved by the European Medicines Agency; therefore, the agency will review any new data on the product annually.

View Arzerra drug record

Further information: GlaxoSmithKline

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