Three studies have scrutinised treatments for oral ulceration. The first, a randomised controlled trial of 19 patients with recurrent aphthous stomatitis, compared pentoxifylline 400mg three times daily with placebo. The benefits of pentoxifylline were limited, although the researchers said it might help those not responding to other treatments.
The second, a retrospective analysis of a case series of 50 patients with oral lichen planus, concluded that a ladder approach to treatment, beginning with topical corticosteroids and moving on to more potent treatments, could achieve substantial lesion regression.
The third study concluded that 1% pimecrolimus cream appears well-tolerated and effective in the treatment of erosive lichen planus.
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