In brief: Irritation from rosacea treatments

The cumulative irritation potential of rosacea treatments has been assessed by US researchers. They investigated the use of metronidazole gel and azelaic acid gel over 21 days in 36 individuals. Azelaic acid gel 15% was found to have a greater potential to produce irritation than metronidazole gel 0.75%, which had a greater irritant potential than metronidazole gel 1%. The researchers stated that metronidazole gel 1% had a similar profile to white paraffin.
Colon LE, Johnson LA, Gottschalk RW. Cutis 2007;79:317-21.

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