In brief: Methotrexate and liver fibrosis

Patients with type-2 diabetes who are receiving methotrexate for psoriasis have an increased risk of severe liver fibrosis, according to the results of a study in Sweden. Researchers reviewed 169 liver biopsies from 71 patients with psoriasis being treated with methotrexate. Of the 26 patients who had one or more of type-2 diabetes, overweight, alcohol over-consumption, or chronic hepatitis B or C, 25 developed fibrosis. Risk of fibrosis for psoriasis patients with one of these other conditions was elevated even when lower cumulative doses of methotrexate were used to treat them.
Rosenberg P, Urwitz H, Johannesson A et al. J Hepatol 2007;46:1111-18.

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