Secukinumab approved by NICE for severe psoriasis

The monoclonal antibody secukinumab (Cosentyx) has been endorsed by NICE for use in patients with severe plaque psoriasis who have not responded to, or have an intolerance or contraindication to, standard systemic therapies

Plaque psoriasis: new treatment for patients with severe disease (Photograph: iStock)
Plaque psoriasis: new treatment for patients with severe disease (Photograph: iStock)
Secukinumab is recommended as an option for adults with a Psoriasis Area Severity Index (PASI) score of 10 or more and a Dermatology Life Quality Index (DLQI) score greater than 10.
Treatment with secukinumab should be stopped if an adequate response is not achieved by 12 weeks. An adequate response is defined as either a 75% reduction in PASI score, or a 50% reduction in PASI score accompanied by a five-point reduction in DLQI score.
Clinicians may need to adjust the DLQI score if the patient has any disabilities or communication difficulties that could affect the assessment.
The decision by NICE is conditional on the manufacturer providing secukinumab with the discount agreed in the patient access scheme.

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