Genetics and environment in rosacea

Researchers in Cleveland, Ohio, have carried out a twin study to determine the relative contribution of genetic and environmental factors to the development of rosacea

The study surveyed identical and fraternal twins regarding risk factors implicated in rosacea. Dermatologists determined a rosacea score for each participant according to the National Rosacea Society (NRS) grading system. Data were collected at the annual Twins Days Festival in Twinsburg, Ohio, in August 2012 and August 2013.
A total of 275 twin pairs (550 individuals) participated in the study. There were 233 identical twin pairs with a mean rosacea score of 2.46 and 42 fraternal twin pairs with a mean rosacea score of 0.75.
There was a higher association of NRS scores between identical versus fraternal twins (r = 0.69 versus r = 0.46, P = 0.04), demonstrating a genetic contribution.
The study found that approximately half of the contribution to the NRS score could be accounted for by genetics and the other half by environment. Correlations were found between rosacea and UV radiation exposure, alcohol, smoking, skin cancer history, cardiac comorbidity and age.
Aldrich N, Gerstenblith M, Fu P et al. JAMA Dermatol August 26, 2015; doi:10.1001/jamadermatol.2015.2230

Want news like this straight to your inbox?
Sign up for our bulletins

Read these next

New topical treatment option for patients with rosacea

Galderma has launched Soolantra, a topical cream containing...

New treatment options and technology in dermatology

New treatment options and technology in dermatology

Several articles in this issue update us on new treatments...

Case reports: Worsening facial redness with flushing episodes

Case reports: Worsening facial redness with flushing episodes

This patient presented with a red complexion, telangiectasia...

Have you registered with us yet?

Register now to enjoy more articles and free email bulletins

Already registered?
Sign in

MIMS Product Slides

Product overviews prepared by the MIMS team, in a handy slide format.

Click here

Slides are initiated, funded & reviewed by the companies specified.

Register or Subscribe to MIMS

GPs can get MIMS print & online and GPonline for free when they register online – take 2 minutes, and make sure you get your free MIMS access! If you're not a GP, you can subscribe to MIMS for full access.

Register or subscribe

MIMS Dermatology

Read the latest issue online exclusively on MIMS Learning.

Read MIMS Dermatology

MIMS Adviser

Especially created for prescribing influencers.

Request free copy

Mobile apps

MIMS: access the full drug database and quick-reference tables on the go

MIMS Diagnosis and Management: concise information on signs and symptoms, investigations and diseases