Sun protection provided in a pill

In an attempt to find a new form of sun protection, researchers from Trinity College Dublin and Mount Sinai Medical Center, New York, investigated the photoprotective properties of extracts from the tropical fern Polypodium leucotomos

The researchers carried out a literature review to analyse photoprotection by supplementation with Polypodium leucotomos (PL), including antioxidant, immunoregulatory, anti-inflammatory and antitumorigenic effects in the context of sunburn, photodermatoses, chronic skin damage, photoageing and skin cancer.
The review indicated that PL supplementation acts at a molecular and cellular level to enhance endogenous antioxidant systems and inhibit generation of reactive oxygen species, which reduces UV-mediated oxidative DNA mutations.
It was also shown to speed up the removal of UV-induced photoproducts.
PL demonstrated some protective effects against photoageing and PUVA-induced phototoxicity by reducing UV-induced inflammatory responses and inhibiting extracellular matrix remodelling. The authors concluded that PL extracts could potentially be administered systemically as a sun-protective agent and could have benefits over the use of suncream in the prevention of skin cancer.
El-Haj N, Goldstein N. Int J Dermatol 2015; 54(3): 362-6
Want news like this straight to your inbox?
Sign up for our bulletins

Have you registered with us yet?

Register now to enjoy more articles and free email bulletins

Already registered?
Sign in

MIMS Product Slides

Product overviews prepared by the MIMS team, in a handy slide format.

Click here

Slides are initiated, funded & reviewed by the companies specified.

Register or Subscribe to MIMS

GPs can get MIMS print & online and GPonline for free when they register online – take 2 minutes, and make sure you get your free MIMS access! If you're not a GP, you can subscribe to MIMS for full access.

Register or subscribe

MIMS Dermatology

Read the latest issue online exclusively on MIMS Learning.

Read MIMS Dermatology

MIMS Adviser

Especially created for prescribing influencers.

Request free copy

Mobile apps

MIMS: access the full drug database and quick-reference tables on the go

MIMS Diagnosis and Management: concise information on signs and symptoms, investigations and diseases