Expanded therapeutic use for melanoma antibody

The monoclonal antibody ipilimumab, indicated for the treatment of adults with advanced melanoma, is now licensed for first-line use


The monoclonal antibody ipilimumab (Yervoy), indicated for the treatment of adults with advanced (unresectable or metastatic) melanoma, is now licensed for first-line use.1

Ipilimumab enhances T-cell mediated responses by blocking the inhibitory signal of cytotoxic T-lymphocyte antigen-4 (CTLA-4). This results in T-cell activation, proliferation and lymphocyte infiltration into tumours, leading to tumour cell death.1

Analysis of pooled data for ipilimumab from phase II and III trials in chemotherapy-naive patients (n=78) showed estimated one- and two-year survival rates of 54.1% (95% CI 42.5-65.6) and 32% (95% CI 20.7-42.9), respectively.

In two retrospective observational studies in treatment-naive patients receiving ipilimumab (n=120 and n=61), estimated
one-year survival rates were 59.5% (95% CI 50.1-67.8) and 49.3% (95% CI 35.6-61.6).1

Reference

1. Yervoy Summary of Product Characteristics, December 2013.

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