Systemic sclerosis

CXCL4 belongs to the CXC family of chemokines and is implicated in the pathogenesis of systemic sclerosis

This is based on study findings that CXCL4 levels are raised in patients with systemic sclerosis and high plasma levels correlate with the presence and progression of complications such as lung fibrosis and pulmonary arterial hypertension.

In a proteome-wide analysis, CXCL4 levels in patients with systemic sclerosis were significantly higher than in controls for patients with rheumatoid arthritis, ankylosing spondylitis and systemic lupus erythematosus.

CXCL4 was the main protein secreted by plasmacytoid dendritic cells from the circulation and skin in those patients with systemic sclerosis.

These results suggest that CXCL4 may be central to the pathogenesis of systemic sclerosis, and therapy aimed at decreasing its activity may prove helpful in managing the disorder.

Van Bon L, Affandi AJ, Broen J et al. N Engl J Med 2014; 370(5): 433-43

Want news like this straight to your inbox?
Sign up for our bulletins

Have you registered with us yet?

Register now to enjoy more articles and free email bulletins

Register
Already registered?
Sign in

More from MIMS

New once-weekly GLP-1 agonist for diabetes

New once-weekly GLP-1 agonist for diabetes

Ozempic (semaglutide) is a glucagon-like peptide-1...

Gluten-free prescribing restricted to bread and mixes

Gluten-free prescribing restricted to bread and mixes

GPs in England are no longer able to prescribe gluten-free...

New vitamin D deficiency thresholds recommended

New vitamin D deficiency thresholds recommended

The National Osteoporosis Society (NOS) has updated...

SGLT2 inhibitors associated with increased risk of lower-limb amputation in new study

SGLT2 inhibitors associated with increased risk of lower-limb amputation in new study

SGLT2 inhibitors may be linked to a doubling in the...