Acanthosis nigricans and insulin resistance Acanthosis nigricans has been closely linked to insulin resistance (IR) and may act as a marker for early onset of type 2 diabetes Sign in to continue Sign In Email address Password Stay signed in Trouble signing in? Reset password: Click here Need help? Email us Register FREE Limited free articles a month Free email bulletins Register Now Subscribe now Benefits include: Full site access Subscriber exclusive content Exclusive bulletins Choose a package